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Tag: monotherapy

Zinc Monotherapy Increases Serum Brain-Derived Neurotrophic Factor (BDNF) Levels and Decreases Depressive Symptoms in Overweight or Obese Subjects: A Double-Blind, Randomized, Placebo-Controlled Trial

This 2015 double-blind, randomized, placebo-controlled trial investigated the effects of zinc monotherapy on depressive symptoms and serum BDNF levels in overweight or obese individuals. Fifty participants were randomized to receive either 30 mg of elemental zinc daily or a placebo for 12 weeks. The study found that zinc supplementation significantly

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June 26, 2025 No Comments

Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

This 2019 study analyzed data from two Phase III trials involving 1,162 patients with mild to moderate Alzheimer’s disease (AD) to assess the relationship between hydromethylthionine (LMTM) plasma concentration and clinical outcomes. Findings revealed that even at a low dose of 8 mg/day, patients with higher plasma levels experienced significant

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June 26, 2025 No Comments

Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial

This Phase III clinical trial evaluated the efficacy of LMTM, a tau aggregation inhibitor, as monotherapy in patients with mild Alzheimer’s disease (AD). The study involved 800 participants randomized to receive either 100 mg or 4 mg of LMTM twice daily. Prior to unblinding, the analysis plan was revised to

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June 26, 2025 No Comments

Thyroxine-triiodothyronine combination therapy versus thyroxine monotherapy for clinical hypothyroidism: meta-analysis of randomized controlled trials

A meta-analysis of 11 randomized controlled trials involving 1,216 patients evaluated the effectiveness of thyroxine (T4) monotherapy compared to combination therapy with thyroxine and triiodothyronine (T3) in treating clinical hypothyroidism. The study found no significant differences between the two treatment approaches in alleviating symptoms such as bodily pain, depression, anxiety,

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June 26, 2025 No Comments