monitoring Archives - Well Referenced

Managing the side effects associated with commonly used treatments for bipolar depression

This 2014 review article discusses the side effects associated with pharmacological treatments for bipolar depression and strategies to manage them. Commonly used medications include mood stabilizers (e.g., lithium, lamotrigine), antipsychotics (e.g., quetiapine, lurasidone), and antidepressants. The article highlights side effects such as weight gain, sedation, gastrointestinal disturbances, and metabolic changes.

June 26, 2025 No Comments

Testosterone Replacement Therapy and Cardiovascular Disease

This review examines the evolving evidence on the cardiovascular safety of testosterone replacement therapy (TRT) in men with hypogonadism. While earlier observational studies raised alarms over increased cardiovascular risks—including myocardial infarction and stroke—recent randomized trials, particularly the TRAVERSE study, provide reassurance that TRT does not significantly increase the risk of

June 26, 2025 No Comments

Static and Dynamic Prognostic Factors of Papillary Thyroid Carcinoma

This 2014 review categorizes prognostic factors of papillary thyroid carcinoma (PTC) into static (e.g., age, tumor size, extrathyroidal extension, lymph node involvement, distant metastasis) and dynamic (postoperative biomarkers such as thyroglobulin [Tg] and thyroglobulin antibodies [TgAb]). While static factors are useful for initial staging and treatment planning, dynamic factors offer

June 26, 2025 No Comments

Active Surveillance for Low-Risk Cancers – A Viable Solution to Overtreatment?

This article discusses the use of active surveillance as a strategy to manage low-risk cancers and avoid overtreatment. It explores the benefits of closely monitoring patients with low-risk cancer types, such as prostate and thyroid cancers, rather than pursuing immediate aggressive treatments. The study suggests that active surveillance can reduce

June 26, 2025 No Comments

A convenient method for measuring blood ascorbate concentrations in patients receiving high-dose intravenous ascorbate

This study presents a convenient method for measuring blood ascorbate (vitamin C) concentrations in patients receiving high-dose intravenous ascorbate. The method offers a more efficient and accurate way to monitor vitamin C levels during treatment, aiding in the optimization of therapy. The study highlights the importance of monitoring ascorbate levels

June 26, 2025 No Comments

Testosterone Treatment in Adult Men With Age-Related Low Testosterone: A Clinical Guideline From the American College of Physicians

This 2020 guideline from the American College of Physicians (ACP) provides evidence-based recommendations on testosterone therapy (TTh) for adult men with age-related low testosterone levels. The ACP advises that clinicians discuss TTh with men experiencing sexual dysfunction related to low testosterone, emphasizing shared decision-making. If no improvement is observed after

June 26, 2025 No Comments

Guideline of Guidelines: Testosterone Therapy for Testosterone Deficiency

This 2019 review by Salter and Mulhall critically compares testosterone therapy (TTh) guidelines from major international medical societies, including the American Urological Association (AUA), Endocrine Society (ES), European Association of Urology (EAU), and others. The consensus across these guidelines emphasizes that TTh should be reserved for men with confirmed testosterone

June 26, 2025 No Comments

10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer

This randomized controlled trial evaluated the long-term outcomes of monitoring, surgery, or radiotherapy in patients with localized prostate cancer. Over a 10-year period, the study found no significant differences in prostate cancer-specific mortality between the three treatment groups. However, surgery and radiotherapy were associated with higher rates of erectile dysfunction

June 26, 2025 No Comments

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