Well Referenced

Tag: migration

Successive Treatment with Naltrexone Induces Epithelial-Mesenchymal Transition and Facilitates the Malignant Biological Behaviors of Bladder Cancer Cells

This 2021 in vitro study examined the impact of chronic naltrexone exposure on bladder cancer cell lines (T24 and MB49). It demonstrated that successive treatment enhanced proliferation, migration, and invasion while inhibiting apoptosis. Mechanistically, naltrexone induced epithelial-mesenchymal transition (EMT) by downregulating epithelial markers (E-cadherin, CK19) and upregulating mesenchymal markers (N-cadherin,

Read More »
June 26, 2025 No Comments

Low-dose naltrexone plays antineoplastic role in cervical cancer progression through suppressing PI3K/AKT/mTOR pathway

This 2021 study investigates the antitumor effects of low-dose naltrexone (LDN) on cervical cancer. LDN treatment upregulated the expression of the opioid growth factor receptor (OGFr) and suppressed the PI3K/AKT/mTOR signaling pathway, leading to reduced proliferation, migration, and invasion of cervical cancer cells in vitro. In vivo, LDN inhibited tumor

Read More »
June 26, 2025 No Comments