This 2014 retrospective case series evaluated the use of intravenous (IV) magnesium sulfate as an acute treatment for headaches in pediatric patients aged 13–18 years. Out of 34 episodes reviewed, 20 met inclusion criteria, comprising 5 cases of migraine, 4 tension-type headaches, and 11 status migrainosus. Patients received a standard
This 1998 review explores magnesium’s role in migraine pathogenesis and treatment. Magnesium deficiency may contribute to migraines by promoting cortical spreading depression, altering neurotransmitter release, and enhancing platelet aggregation. Clinical studies indicate that intravenous magnesium can provide rapid relief during acute migraine attacks, while oral supplementation may serve as a
This prospective quasi-experimental study evaluated the analgesic efficacy of intravenous caffeine citrate (60 mg) versus magnesium sulfate (2 g) in 70 adult patients presenting with acute migraine headaches in an emergency department in Tehran, Iran. Pain was assessed using the Visual Analog Scale (VAS) at baseline, and one and two
This article emphasizes the critical role of magnesium in migraine management, advocating for its routine use in all migraine patients due to its potential to reduce migraine frequency and intensity. Magnesium is involved in several processes that may influence migraine pathogenesis, including cortical spreading depression, platelet aggregation, and serotonin receptor
This systematic review highlights the essential role of magnesium in over 300 enzymatic reactions and its broad therapeutic potential across various health domains. Magnesium deficiency is linked to numerous chronic diseases including Alzheimer’s, insulin resistance, type 2 diabetes, hypertension, cardiovascular conditions, migraines, and ADHD. The review underscores magnesium’s physiological importance
This 2022 randomized, double-blind, placebo-controlled trial published in Scientific Reports (DOI: 10.1038/s41598-021-04397-z, PMID: 34997178) evaluated the effects of alpha-lipoic acid (ALA) supplementation in 92 women with episodic migraines. Over 3 months, participants receiving 300 mg/day of ALA experienced significant reductions in headache frequency, severity, and duration, along with decreased levels
A systematic review published in the Cochrane Database of Systematic Reviews (2015) analyzed 12 trials with 201 participants to evaluate the effectiveness of normobaric oxygen therapy (NBOT) and hyperbaric oxygen therapy (HBOT) for treating and preventing migraines and cluster headaches. The findings suggest that NBOT is effective in providing rapid
This review examines the relationship between estrogen replacement therapy (ERT) and migraines in postmenopausal women, highlighting that stable estrogen levels achieved through ERT may help reduce migraine frequency in some individuals while triggering migraines in others. The study emphasizes the need for a personalized approach, as fluctuations in estrogen are
