Tag: midlife

Obesity associated with increased brain age from midlife

This neuroimaging study assessed how obesity impacts brain structure across the adult lifespan using MRI data from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) cohort. Analyzing 527 individuals aged 20–87, researchers found that overweight and obese adults—especially those in midlife—had significantly reduced white matter volume compared to their lean

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Systemic inflammation during midlife and cognitive change over 20 years: The ARIC Study

This prospective cohort study analyzed data from 12,336 participants (mean age 56.8 years) in the Atherosclerosis Risk in Communities (ARIC) study to assess the relationship between midlife systemic inflammation and cognitive decline over two decades. Researchers measured inflammatory biomarkers—fibrinogen, white blood cell count, von Willebrand factor, and factor VIII—to create

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