Well Referenced

Tag: microRNA

Zinc Gluconate Induces Potentially Cancer Chemopreventive Activity in Barrett’s Esophagus: A Phase 1 Pilot Study

This 2021 Phase 1 pilot study investigated the chemopreventive potential of oral zinc gluconate in patients with Barrett’s esophagus (BE), a precancerous condition. Participants received 26.4 mg of zinc gluconate twice daily for 14 days prior to surveillance endoscopy. Biopsies from the Barrett’s mucosa were analyzed for molecular changes. The

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June 26, 2025 No Comments

Prospective of Colon Cancer Treatments and Scope for Combinatorial Approach to Enhanced Cancer Cell Apoptosis

This 2012 review explores current and emerging therapies for colorectal cancer, emphasizing the potential of combinatorial approaches to enhance apoptosis in cancer cells. It discusses traditional treatments like surgery and chemotherapy, as well as novel strategies involving immunotherapy, gene therapy, and targeted molecular treatments. The review highlights the role of

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June 26, 2025 No Comments

Prostate Cancer Detection and Prognosis: From Prostate Specific Antigen (PSA) to Exosomal Biomarkers

This 2014 review addresses the shortcomings of PSA as a biomarker for prostate cancer, including low specificity and the resulting overdiagnosis and overtreatment. It explores the promise of exosomal biomarkers—extracellular vesicles containing nucleic acids and proteins—as more precise, non-invasive diagnostic and prognostic tools. Exosomes isolated from blood, urine, and other

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June 26, 2025 No Comments

Epigenetic impacts of ascorbate on human metastatic melanoma cells

This 2014 study explores how pharmacological doses of ascorbate (vitamin C) impact the epigenetic landscape of human metastatic melanoma cells. Researchers found that high concentrations of ascorbate (8 mM) significantly inhibited DNA methyltransferase (DNMT) activity but had no effect on histone deacetylase (HDAC) function. Additionally, ascorbate treatment resulted in the

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June 26, 2025 No Comments