Tag: microglia activation

This 2019 in vivo study published in Scientific Reports (DOI: 10.1038/s41598-019-42286-8) explored the effects of lipopolysaccharide (LPS)-induced neuroinflammation on cognition in mice. LPS administration activated microglia, increased pro-inflammatory cytokines (TNF-α, IL-1β), decreased anti-inflammatory cytokines (IL-4, IL-10), and impaired memory performance in behavioral tests. It also triggered NF-κB pathway activation and