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The monoamine oxidase inhibition properties of selected structural analogues of methylene blue

This in vitro study examined the inhibitory effects of five structural analogues of methylene blue (MB)—neutral red, Nile blue, new methylene blue, cresyl violet, and 1,9-dimethyl methylene blue—on human monoamine oxidase (MAO) enzymes. The results demonstrated that all analogues selectively inhibited the MAO-A isoform, with cresyl violet (IC₅₀ = 0.0037

June 26, 2025 No Comments

Methylene Blue Analogues with Marginal Monoamine Oxidase Inhibition Retain Antidepressant-like Activity

This study investigated five newly synthesized methylene blue (MB) analogues with low monoamine oxidase A (MAO-A) inhibitory activity to assess their antidepressant-like effects. In rats, these analogues exhibited significant antidepressant effects in the forced swim test (FST), similar to imipramine and MB, without affecting locomotor activity. Their IC₅₀ values for

June 26, 2025 No Comments

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The monoamine oxidase inhibition properties of selected structural analogues of methylene blue

Methylene Blue Analogues with Marginal Monoamine Oxidase Inhibition Retain Antidepressant-like Activity