Glutathione levels are associated with methotrexate resistance in acute lymphoblastic leukemia cell lines
This study explores how intracellular glutathione (GSH) levels contribute to methotrexate (MTX) resistance in acute lymphoblastic leukemia (ALL) cell lines. Using metabolomic and gene expression analysis across 13 ALL lines, researchers found elevated GSH levels were associated with MTX resistance, indicating a constitutive metabolic defense mechanism. Key genes involved in
June 26, 2025
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