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Tag: methionine cycle

One-Carbon Metabolism: Pulling the Strings behind Aging and Neurodegeneration

This 2022 review explores the pivotal role of one-carbon metabolism (OCM) in aging and neurodegeneration. OCM encompasses interconnected pathways like the folate and methionine cycles, crucial for DNA synthesis, methylation, redox balance, and mitochondrial function. The authors highlight how disruptions in OCM contribute to age-related diseases, including Alzheimer’s and Parkinson’s,

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June 26, 2025 No Comments

Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin Users

This review explores how metformin, beyond its glucose-lowering effects, influences one-carbon metabolism by inhibiting mitochondrial complex I, leading to alterations in folate and methionine cycles. These changes can impair DNA methylation, nucleotide synthesis, and redox balance, potentially affecting cellular proliferation and aging processes. The authors discuss the implications of these

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June 26, 2025 No Comments

Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups

This in vitro and animal study explored the role of the PNPLA8-PNPLA7 enzymatic axis in hepatic phosphatidylcholine (PC) catabolism and its impact on methyl group metabolism. The study found that PNPLA7-deficient and PNPLA8-deficient mice exhibited decreased hepatic glycerophosphocholine (GPC), choline, and methionine cycle metabolites, leading to metabolic imbalances such as

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June 26, 2025 No Comments