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Tag: methioninase

Pilot Phase I Clinical Trial of Methioninase on High-Stage Cancer Patients: Rapid Depletion of Circulating Methionine

This Phase I clinical trial evaluated the safety and efficacy of methioninase (METase) and recombinant methioninase (rMETase) in depleting serum methionine (MET) levels in high-stage cancer patients. MET dependence is a metabolic vulnerability in cancer cells, making MET depletion a potential therapeutic strategy. Three patients received non-recombinant METase, showing significant

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June 26, 2025 No Comments

A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension

This review examines the role of methionine dependency in cancer cells and the potential benefits of methionine restriction in cancer growth control and life-span extension. The review highlights that cancers exhibiting methionine dependence can be targeted by reducing methionine availability, either through dietary changes (e.g., vegan diets) or methionine-depleting therapies

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June 26, 2025 No Comments