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Tag: metal chelation therapy

Challenges and Opportunities of Metal Chelation Therapy in Trace Metals Overload-Induced Alzheimer’s Disease

This 2023 review examines the role of trace metal dyshomeostasis—particularly involving copper (Cu), zinc (Zn), and iron (Fe)—in Alzheimer’s disease (AD) pathogenesis. It highlights how abnormal accumulation of these metals contributes to amyloid-β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, and neuroinflammation. The study evaluates various chelating agents, such as deferoxamine,

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June 26, 2025 No Comments

Metal chelation therapy in rheumathoid arthritis: a case report. Successful management of rheumathoid arthritis by metal chelation therapy

This case report discusses a 63-year-old Italian woman with rheumatoid arthritis (RA) who was found to have elevated levels of aluminum, cadmium, and lead. She underwent metal chelation therapy, which resulted in significant clinical improvement of her RA symptoms, suggesting a possible link between heavy metal exposure and autoimmune diseases.

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June 26, 2025 No Comments

Metal chelators and neurotoxicity: lead, mercury, and arsenic

This review examines the use of metal chelators, including DMSA, DMPS, and CaEDTA, in treating lead, mercury, and arsenic poisoning, with a focus on their efficacy, safety, and potential combination therapies. The study highlights that DMSA is a safer alternative to CaEDTA for moderate lead poisoning and suggests that DMSA

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June 26, 2025 No Comments