Well Referenced

Tag: metabolomics

1H NMR-based metabolomic study of metabolic profiling for pollinosis

This 2019 study utilized proton nuclear magnetic resonance (^1H NMR) spectroscopy to analyze serum samples from 37 patients with pollinosis (seasonal allergic rhinitis) during symptomatic (seizure) and asymptomatic (remission) phases. The analysis revealed significant metabolic alterations during the symptomatic phase, including decreased levels of branched-chain amino acids (isoleucine, leucine, valine),

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June 26, 2025 No Comments

Clinical and metabolomic predictors of regression to normoglycemia in a population at intermediate cardiometabolic risk

This cohort study evaluated clinical and metabolomic factors predicting regression from impaired fasting glucose (IFG) to normoglycemia among 491 Mexican adults at intermediate cardiometabolic risk over a 2.5-year period. Key findings showed 22.6% reverted to normal glucose levels, with younger age, lower BMI, and lower fasting glucose significantly predicting regression.

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June 26, 2025 No Comments

Glutathione levels are associated with methotrexate resistance in acute lymphoblastic leukemia cell lines

This study explores how intracellular glutathione (GSH) levels contribute to methotrexate (MTX) resistance in acute lymphoblastic leukemia (ALL) cell lines. Using metabolomic and gene expression analysis across 13 ALL lines, researchers found elevated GSH levels were associated with MTX resistance, indicating a constitutive metabolic defense mechanism. Key genes involved in

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June 26, 2025 No Comments