This 2016 study investigated the metabolic effects of vitamin C on KRAS mutant colorectal cancer (CRC) cells. It found that vitamin C disrupts the Warburg effect by impairing glycolysis through several mechanisms: detachment of RAS from the plasma membrane, inhibition of ERK1/2 signaling, and reduction in PKM2 Ser37 phosphorylation. These
This conceptual review explores how the Warburg effect—characterized by cancer cells favoring aerobic glycolysis over oxidative phosphorylation—intersects with the established hallmarks of cancer. The authors argue that this metabolic reprogramming is not merely a consequence but a driver of tumorigenesis. The shift to glycolysis results in reduced ATP yield, compelling
The article “Dichloroacetate (DCA) and Cancer: An Overview towards Clinical Applications” (Oxidative Medicine and Cellular Longevity, 2019, PMID: 31827705) reviews the potential of DCA in cancer therapy, discussing its mechanism of action in targeting cancer cell metabolism by shifting energy production from glycolysis to mitochondrial oxidation. It highlights DCA’s ability
