Tag: Metabolic Modulation

Probiotic strains and mechanistic insights for the treatment of type 2 diabetes

This 2017 review examines the role of specific probiotic strains, particularly from the Lactobacillus and Bifidobacterium genera, in managing type 2 diabetes (T2D). It highlights that alterations in gut microbiota composition are associated with T2D and that probiotics may offer therapeutic benefits by modulating this microbiota. The review emphasizes the

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Potential therapeutic applications of thyroid hormone analogs

This review explores the development and potential therapeutic applications of thyroid hormone analogs, which are designed to replicate the beneficial effects of thyroid hormones—such as enhanced cardiac function, weight loss, and reduced serum cholesterol—while minimizing adverse effects on the heart, bone, and skeletal muscle. These analogs have been studied for

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α-Lipoic acid sensitizes lung cancer cells to chemotherapeutic agents and anoikis via integrin β1/β3 downregulation

The study titled “α-Lipoic acid sensitizes lung cancer cells to chemotherapeutic agents and anoikis via integrin β1/β3 downregulation” (PMID: 27431988) explored the effects of α-lipoic acid (LA) on lung cancer cells. This in vitro study found that LA increased reactive oxygen species levels, leading to the downregulation of integrin β1

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