This 2014 review article examines the role of testosterone supplementation therapy (TST) in men with metabolic syndrome (MetS). MetS is characterized by a cluster of conditions including increased waist circumference, high triglyceride levels, low HDL cholesterol, high blood pressure, and insulin resistance, which collectively elevate the risk of type 2
This 2015 commentary discusses a study involving 1,023 hypogonadal men undergoing testosterone therapy (TST) across three registries with a median follow-up of five years. The study found prostate cancer incidences of 2.3% and 1.5% in two cohorts, with no cases in the third. These rates are lower than those reported
This Phase IV randomized, double-blind, placebo-controlled trial assessed the efficacy and safety of Tribulus terrestris (TT; Tribestan®) in 180 men aged 18–65 with mild to moderate erectile dysfunction (ED), with or without hypoactive sexual desire disorder (HSDD). Participants received 1,500 mg/day of TT (3×2 tablets) or placebo for 12 weeks.
This study evaluated the impact of L-thyroxine therapy on sexual function and depressive symptoms in men with autoimmune hypothyroidism. Participants were divided into three groups: men with overt hypothyroidism, men with subclinical hypothyroidism, and healthy controls. Over six months, L-thyroxine treatment led to significant improvements in erectile function, intercourse satisfaction,
This randomized, double-blind, placebo-controlled trial investigated the distinct roles of testosterone and estradiol in regulating body composition, muscle strength, and sexual function in men. Healthy men aged 20–50 underwent pharmacological suppression of endogenous gonadal steroids and received varying doses of testosterone gel, with or without an aromatase inhibitor to block
This systematic review and meta-analysis evaluated the efficacy of saffron (Crocus sativus) in treating sexual dysfunction across genders. Analyzing five randomized controlled trials encompassing 173 participants, the study found that saffron significantly improved overall sexual dysfunction (standardized mean difference [SMD] = 0.811; 95% CI: 0.356–1.265) and its subdomains (SMD =
This single-blind study evaluated the efficacy of oral L-citrulline supplementation in 24 men with mild erectile dysfunction (ED), characterized by an erection hardness score (EHS) of 3. Participants received a placebo for one month, followed by 1.5 g/day of L-citrulline for another month. Results showed that 50% of the men
This 12-week double-blind, placebo-controlled, randomized trial investigated the effects of gelatinized maca (Lepidium meyenii) on sexual desire and hormone levels in 57 healthy men aged 21–56. Participants received either 1,500 mg or 3,000 mg of maca daily or a placebo. Self-perception of sexual desire was assessed at 4, 8, and
This double-blind, placebo-controlled study assessed the efficacy of naltrexone, an opioid receptor antagonist, in treating idiopathic erectile dysfunction (ED) in 20 otherwise healthy men aged 23.9–63.3 years. Participants received 25 mg/day of naltrexone or placebo for 4 weeks, followed by 50 mg/day or placebo for another 4 weeks. Daily logs
In this 2017 systematic review, Fojecki et al. evaluated the efficacy of extracorporeal shock wave therapy (ESWT) in treating Peyronie’s disease (PD), erectile dysfunction (ED), and chronic pelvic pain syndrome (CPPS). The authors analyzed multiple randomized controlled trials and observational studies to assess the outcomes of ESWT on these urological
