Well Referenced

Tag: MDA

Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials

This systematic review and meta-analysis examined the effects of curcumin/turmeric supplementation on inflammatory and oxidative stress markers across 66 randomized controlled trials. The results showed significant reductions in C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6), along with improvements in total antioxidant capacity (TAC), superoxide dismutase (SOD) activity,

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June 26, 2025 No Comments

A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress

This systematic review examines malondialdehyde (MDA), a product of polyunsaturated fatty acid peroxidation, highlighting its role as a toxic molecule and a biomarker of oxidative stress. MDA forms adducts with DNA and proteins, contributing to mutagenesis and atherogenesis, with elevated levels observed in oxidative stress-related conditions such as cardiovascular diseases

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June 26, 2025 No Comments

Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges

This systematic review examines the challenges in assessing lipid peroxidation through biomarkers such as malondialdehyde (MDA), 4-hydroxy-nonenal (HNE), and 15(S)-8-iso-prostaglandin F₂α (15(S)-8-iso-PGF₂α), which indicate oxidative stress and cellular damage. These markers originate from both enzymatic and non-enzymatic reactions involving polyunsaturated fatty acids (PUFAs), complicating their accurate quantification. The review highlights

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June 26, 2025 No Comments

The effects of L-carnitine supplementation on indicators of inflammation and oxidative stress: a systematic review and meta-analysis of randomized controlled trials

This systematic review and meta-analysis examined the effects of L-carnitine supplementation on inflammation and oxidative stress markers by analyzing data from multiple randomized controlled trials. The results indicated that L-carnitine supplementation significantly reduced key inflammatory markers such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), as well

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June 26, 2025 No Comments