This 2023 retrospective study compared clomiphene citrate (CC) and enclomiphene citrate (EC) in treating male infertility and hypogonadism. Among 78 men (46 on EC, 32 on CC), both treatments significantly increased serum testosterone levels. However, only EC led to significant rises in FSH and LH levels and improved total motile
This review examines the impact of oxidative stress (OS) on male infertility and the potential protective effects of antioxidants. OS, resulting from an imbalance between reactive oxygen species (ROS) and antioxidant defenses, can impair sperm function by causing lipid peroxidation, DNA damage, and apoptosis. The article discusses various antioxidants, including
This study evaluated clomiphene citrate (CC) for safety in male patients with infertility or hypogonadism. Over 12 months, it found that CC significantly increased testosterone without affecting PSA or haematocrit levels. The study included 77 men aged 22-51, all treated with 50 mg daily or every other day. CC showed
The study titled “Combination therapy with clomiphene citrate and anastrozole is a safe and effective alternative for hypoandrogenic subfertile men,” published in BJU International (2018, PMID: 29873446), examined the efficacy and safety of combining clomiphene citrate (CC) with anastrozole (AZ) in men with hypoandrogenism and subfertility. This observational study of
