male health Archives - Well Referenced

Platelet-Rich Plasma (PRP) Improves Erectile Function: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial

This study investigates the efficacy of Platelet-Rich Plasma (PRP) injections in improving erectile function in men with mild erectile dysfunction (ED). Conducted as a double-blind, randomized, placebo-controlled trial, it found that PRP treatment significantly improved erectile function compared to a placebo (p < 0.05). PRP is derived from the patient's

June 26, 2025 No Comments

The efficacy of platelet rich plasma in the treatment of erectile dysfunction: a systematic review and meta-analysis of randomized controlled trials

This meta-analysis evaluated the efficacy of platelet-rich plasma (PRP) therapy in treating erectile dysfunction (ED) by analyzing four randomized controlled trials (RCTs) with 413 participants. PRP therapy significantly improved erectile function compared to placebo, as measured by the International Index of Erectile Function (IIEF) scores at one, three, and six

June 26, 2025 No Comments

Erection hardness: a unifying factor for defining response in the treatment of erectile dysfunction

This observational study analyzed data from 6,549 men with erectile dysfunction (ED) to evaluate the relationship between erection hardness, assessed using the Erection Hardness Grading Scale (EHGS), and various measures of erectile function. Nearly 50% of men with severe ED (IIEF EF domain score ≤10) improved to no ED (IIEF

June 26, 2025 No Comments

Alterations in Pregnenolone and Testosterone Levels in Male Shift Workers

This study examines the effects of shift work on hormone levels in male workers, specifically focusing on pregnenolone and testosterone. It found that shift workers exhibited significantly lower serum levels of these hormones compared to daytime workers, likely due to disruptions in their circadian rhythms caused by irregular sleep-wake cycles.

June 26, 2025 No Comments

Meta-analysis of Results of Testosterone Therapy on Sexual Function Based on International Index of Erectile Function Scores

This meta-analysis evaluated the effects of testosterone therapy (TTh) on male sexual function using the International Index of Erectile Function (IIEF) scores. The results showed significant improvement in erectile function and sexual satisfaction in men with low testosterone, especially in those with initially low testosterone levels. Testosterone therapy was found

June 26, 2025 No Comments

Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males

This observational study investigated the effects of age, BMI, insulin, growth hormone (GH), and insulin-like growth factor I (IGF-I) on sex hormone-binding globulin (SHBG) and androgen levels in 250 non-obese and 50 obese men. Findings showed that age and BMI were inversely correlated with androgen levels, while SHBG was negatively

June 26, 2025 No Comments

Cardiovascular Safety of Testosterone-Replacement Therapy

This study evaluated the cardiovascular safety of testosterone replacement therapy in men aged 45-80 with hypogonadism and cardiovascular risk. It found that testosterone therapy did not increase cardiovascular risk, showing noninferiority to the placebo. This research supports the safety of testosterone for long-term use in men with metabolic concerns and

June 26, 2025 No Comments

Clomiphene citrate is safe and effective for long-term management of hypogonadism

This observational study evaluated the long-term safety and efficacy of clomiphene citrate (CC) for managing hypogonadism in men. The study followed 46 men (mean age 44) with baseline testosterone levels averaging 228 ng/dL, showing significant increases to 612 ng/dL at 1 year, 562 ng/dL at 2 years, and 582 ng/dL

June 26, 2025 No Comments

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