This 2015 review by Stewart J. Tepper evaluates the evidence supporting nutraceutical, biobehavioral, and physical treatments for migraine and other headache disorders. For migraine prevention in adults, Level B evidence supports the use of feverfew, magnesium, and riboflavin (vitamin B2). Coenzyme Q10 (CoQ10) has Level C evidence, while melatonin has
This 2002 review by Dr. Alan R. Gaby discusses the clinical application of the “Myers’ cocktail,” an intravenous vitamin and mineral formula originally developed by Dr. John Myers. The modified cocktail typically includes magnesium, calcium, B vitamins, and vitamin C. Over an 11-year period, approximately 15,000 injections were administered to
This 1998 review explores magnesium’s role in migraine pathogenesis and treatment. Magnesium deficiency may contribute to migraines by promoting cortical spreading depression, altering neurotransmitter release, and enhancing platelet aggregation. Clinical studies indicate that intravenous magnesium can provide rapid relief during acute migraine attacks, while oral supplementation may serve as a
This 2012 cohort study published in Magnesium Research analyzed data from 4,107 U.S. adults in the NHANES 2001–2006 dataset to examine the relationship between magnesium intake and serum vitamin D levels. The findings showed that higher magnesium intake was significantly associated with increased serum 25(OH)D levels and a lower risk
This article from Medical News Today provides an overview of various types of magnesium supplements, including magnesium citrate, magnesium oxide, magnesium glycinate, magnesium sulfate, and magnesium chloride, discussing their specific health benefits, uses, and potential side effects. Magnesium plays a crucial role in supporting muscle function, bone health, heart rhythm,
This article provides a review of the use of nutraceuticals, including magnesium, riboflavin, coenzyme Q10, feverfew, and butterbur, for migraine prophylaxis. It highlights the growing body of evidence supporting the efficacy of these non-pharmacological treatments in reducing the frequency and severity of migraines, especially for patients dissatisfied with conventional medications.
This article emphasizes the critical role of magnesium in migraine management, advocating for its routine use in all migraine patients due to its potential to reduce migraine frequency and intensity. Magnesium is involved in several processes that may influence migraine pathogenesis, including cortical spreading depression, platelet aggregation, and serotonin receptor
This 2017 systematic review examined the effects of magnesium (Mg) on exercise performance, analyzing both animal and human studies. The findings suggest that magnesium supplementation can enhance physical performance by improving glucose availability, reducing lactate accumulation, and supporting muscle energy metabolism. In human studies, higher magnesium status correlated with better
This 2012 review and in vitro/animal study explored the critical role of magnesium (Mg) in slowing aging processes, with a focus on insights from space flight research, where microgravity-induced Mg depletion accelerates aging. Findings indicate that Mg deficiency contributes to elevated catecholamines, oxidative stress, insulin resistance, inflammation, endothelial damage, and
This 2014 review article explores the roles of essential elements—zinc, magnesium, lithium, iron, calcium, and chromium—in the development and treatment of depression and anxiety. It highlights evidence from preclinical and clinical studies linking deficiencies in these elements to mood disorders and notes that supplementation may improve the efficacy of antidepressants
