This 2021 comprehensive review article provides an in-depth analysis of Lyme disease, a tick-borne illness caused by Borrelia burgdorferi sensu lato complex. The disease is prevalent across the Northern Hemisphere and is transmitted by ticks from the Ixodes ricinus complex. The article discusses the increasing global incidence of Lyme disease,
This 2005 prospective, open-label, randomized, multicenter trial compared 14-day versus 28-day intravenous ceftriaxone regimens in 143 serologically confirmed patients with late Lyme disease. Clinical cure rates were 76% for the 14-day group and 70% for the 28-day group (p = NS). While there were more treatment failures in the 14-day
This observational study reviewed 218 patient charts from a Rhode Island outpatient Lyme and tick-borne disease clinic, highlighting the challenges in diagnosing and managing post-treatment Lyme disease syndrome (PTLDS). Common symptoms included fatigue (66.5%), joint pain (58.2%), cognitive difficulties (32.1%), and headaches (27.9%). Over half of the patients with symptoms
