This observational study investigated the prevalence of prostate cancer in 345 hypogonadal men with PSA levels of 4.0 ng/mL or less, finding a 15.1% overall cancer detection rate. The prevalence increased with PSA levels, ranging from 5.6% in men with PSA ≤1.0 ng/mL to 36.4% in those with PSA 3.1–4.0
This meta-analysis evaluated the effects of testosterone therapy (TTh) on male sexual function using the International Index of Erectile Function (IIEF) scores. The results showed significant improvement in erectile function and sexual satisfaction in men with low testosterone, especially in those with initially low testosterone levels. Testosterone therapy was found
This systematic review and meta-analysis assessed the effectiveness of testosterone replacement therapy (TRT) across different administration routes (oral, transdermal, and intramuscular) on muscle mass and strength. The findings revealed that intramuscular TRT was the most effective at improving muscle mass and strength, with transdermal and oral routes showing less significant
A randomized controlled trial published in Urology (2014) examined the efficacy of tadalafil 5 mg once daily in men with erectile dysfunction (ED) and partial response to on-demand PDE5 inhibitors (PDE5Is), assessing the role of testosterone levels. The study included men aged 18 and older with at least a 3-month
