Time, symptom burden, androgen deprivation, and self-assessed quality of life after radical prostatectomy or watchful waiting: the Randomized Scandinavian Prostate Cancer Group Study Number 4 (SPCG-4) clinical trial
This randomized controlled trial compared radical prostatectomy (RP) with watchful waiting (WW) in 695 men with early prostate cancer over a median follow-up of 12 years, assessing symptom burden, androgen deprivation therapy (ADT) use, and quality of life (QoL). RP was associated with lower prostate cancer-specific mortality but higher rates