Well Referenced

Tag: localized prostate cancer

Re: Fifteen-Year Outcomes After Monitoring, Surgery, or Radiotherapy for Prostate Cancer

This 2023 expert commentary discusses the 15-year follow-up results of the ProtecT trial, which compared active monitoring, radical prostatectomy, and radiotherapy in men with localized prostate cancer. The trial found no statistically significant difference in prostate cancer-specific mortality among the three treatment modalities, with overall mortality remaining low across the

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June 26, 2025 No Comments

Active monitoring, radical prostatectomy, or radiotherapy for localised prostate cancer: study design and diagnostic and baseline results of the ProtecT randomised phase 3 trial

The ProtecT trial is a randomized controlled trial that compared active monitoring, radical prostatectomy, and radiotherapy for men with localized prostate cancer. It involved 1,643 participants and aimed to provide contemporary data on the outcomes of these treatment options. The study found no significant difference in prostate cancer-specific mortality between

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June 26, 2025 No Comments

Management of localised prostate cancer: watchful waiting, surgery or radiation therapy, depending on the natural course, which is often relatively slow

This review article examines the management of localized prostate cancer, highlighting watchful waiting, radical prostatectomy, and radiation therapy as primary treatment options. It emphasizes that prostate cancer often progresses slowly, particularly in men over 65, making active surveillance a viable option for many patients. The choice of treatment should be

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June 26, 2025 No Comments

Prostate cancer–uncertainty and a way forward

This editorial discusses the findings of a study comparing radical prostatectomy to observation in men with localized prostate cancer, emphasizing the uncertainty in determining the optimal management strategy. The study found no significant difference in all-cause mortality between men undergoing surgery and those under observation, though surgery reduced disease-specific mortality

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June 26, 2025 No Comments

Radical prostatectomy versus observation for localized prostate cancer

This randomized controlled trial compared radical prostatectomy with observation in 731 men with clinically localized prostate cancer over a median follow-up of 10 years. The study found no significant reduction in all-cause mortality (47.0% vs. 49.9%; HR 0.88; 95% CI, 0.71–1.08; P=0.22) or prostate-cancer-specific mortality (5.8% vs. 8.4%; HR 0.63;

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June 26, 2025 No Comments