This 2014 review investigates the potential risk of iatrogenic tumor cell seeding during diagnostic interventions such as biopsy and fine-needle aspiration cytology (FNAC). Drawing from literature spanning 1983 to 2012, the article highlights documented cases where tumor cells were dislodged and implanted along needle tracts, contributing to local recurrence or
This study investigates the effects of berberine on human hepatoma cell invasion and its impact on healthy hepatocytes. The findings show that berberine effectively inhibits the invasive behavior of hepatoma cells, a key factor in liver cancer metastasis, without causing cytotoxicity to normal hepatocytes. These results suggest that berberine may
This systematic review explores the role of choline metabolism in nonalcoholic fatty liver disease (NAFLD) and liver cancer, highlighting its key pathways: oxidation, phosphorylation, and acetylation. Choline’s oxidation produces betaine, which aids in methylation and epigenetic regulation, while phosphorylation impacts lipid metabolism and transport. Acetylation results in the formation of
This study explores the role of progesterone and related compounds in hepatocellular carcinoma (HCC), analyzing their potential impact on the disease’s development and treatment. HCC is more prevalent in men than women, suggesting a role for sex hormones in its pathogenesis. The study reviews how progesterone and synthetic progestins, such
