Well Referenced

Tag: lifestyle intervention

Pharmacological Management of Obesity: An Endocrine Society Clinical Practice Guideline

This 2015 guideline by the Endocrine Society provides evidence-based recommendations for the pharmacological treatment of obesity. It emphasizes that lifestyle interventions—diet, exercise, and behavioral modifications—should be the foundation of obesity management for individuals with a BMI ≥25 kg/m². Pharmacotherapy is recommended as an adjunct for patients with a BMI ≥27

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June 26, 2025 No Comments

AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY COMPREHENSIVE CLINICAL PRACTICE GUIDELINES FOR MEDICAL CARE OF PATIENTS WITH OBESITY

These comprehensive guidelines, developed by AACE and ACE, provide evidence-based recommendations for the medical care of patients with obesity. The guidelines address nine broad clinical questions, resulting in 123 recommendations encompassing 160 specific statements. Key areas include screening, diagnosis, clinical evaluation, treatment options, therapy selection, and treatment goals. The guidelines

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June 26, 2025 No Comments

Indian Academy of Pediatrics Revised Guidelines on Evaluation, Prevention and Management of Childhood Obesity

The 2023 Indian Academy of Pediatrics (IAP) guidelines update the 2004 recommendations on childhood obesity, addressing the rising prevalence and evolving understanding of its pathogenesis and management. The guidelines emphasize distinguishing primary (exogenous) from secondary (endogenous) obesity, as management strategies differ. For diagnosis, weight-for-length/height using WHO charts is recommended for

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June 26, 2025 No Comments

TSH and free triiodothyronine concentrations are associated with weight loss in a lifestyle intervention and weight regain afterwards in obese children

This prospective study investigated the relationship between thyroid hormone levels and weight changes in 51 obese children undergoing a 1-year lifestyle intervention. The study found that higher baseline thyroid-stimulating hormone (TSH) levels were associated with greater weight loss during the intervention, while higher free triiodothyronine (fT3) levels correlated with weight

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June 26, 2025 No Comments

Testosterone and metabolic syndrome

This review explores the complex relationship between testosterone levels and metabolic syndrome (MetS) in men. Low total testosterone (TT) and sex hormone-binding globulin (SHBG) levels are commonly observed in men with MetS, primarily due to hyperinsulinemia and increased inflammatory cytokines associated with obesity. Low SHBG levels have been identified as

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June 26, 2025 No Comments

Sustained weight loss following 12-month pramlintide treatment as an adjunct to lifestyle intervention in obesity

This 12-month, randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of pramlintide, an amylin analog, as an adjunct to lifestyle intervention (LSI) in 411 obese, non-diabetic adults. Participants were assigned to various dosing regimens of pramlintide (120, 240, or 360 µg administered twice or three times daily) or placebo,

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June 26, 2025 No Comments

The effect of glucagon-like peptide-1 receptor agonist therapy on body mass index in adolescents with severe obesity: a randomized, placebo-controlled, clinical trial

This 3-month, randomized, double-blind, placebo-controlled clinical trial evaluated the efficacy and safety of exenatide, a GLP-1 receptor agonist, in 26 adolescents aged 12–19 years with severe obesity (BMI ≥1.2 times the 95th percentile or ≥35 kg/m²). Participants received lifestyle counseling and were randomized to exenatide (twice daily) or placebo. Exenatide

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June 26, 2025 No Comments