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Tag: leukocyte DNA

Detection of 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker of oxidative damage in peripheral leukocyte DNA by UHPLC-MS/MS

This study investigated the detection of 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker of oxidative DNA damage using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) in peripheral leukocyte DNA. Elevated 8-OHdG levels have been linked to various conditions, including cardiovascular diseases and metabolic disorders, making it a valuable marker for assessing oxidative stress.

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June 26, 2025 No Comments

Active and passive smoking and lifestyle determinants of 8-oxo-7,8-dihydro-2′-deoxyguanosine levels in human leukocyte DNA

This observational study examined the impact of active and passive smoking on oxidative DNA damage by measuring 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) levels in leukocyte DNA. Findings revealed that active smokers exhibited significantly higher oxidative DNA damage compared to non-smokers, while passive smokers also had elevated levels, though to a lesser extent. Other

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June 26, 2025 No Comments