Well Referenced

Tag: Leukemia

Cytotoxic effects of high concentrations of sodium ascorbate on human myeloid cell lines

This 2015 study investigates the cytotoxic potential of pharmacologic doses of sodium ascorbate (vitamin C) on several human myeloid leukemia cell lines, including HL60, U937, NB4, NB4-R4 (retinoic acid-resistant), NB4/AsR (arsenic trioxide-resistant), and K562. Results showed that sodium ascorbate induced dose-dependent apoptosis with an LC50 around 3 mM, primarily through

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June 26, 2025 No Comments

Artesunate possesses anti-leukemia properties that can be enhanced by arsenic trioxide

This study investigates the anti-leukemia effects of artesunate, a drug traditionally used for malaria, and its potential synergy with arsenic trioxide. The research shows that artesunate inhibits leukemia cell proliferation and induces apoptosis. Furthermore, when combined with arsenic trioxide, artesunate’s therapeutic efficacy is significantly enhanced, making it a promising combination

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June 26, 2025 No Comments