This review article explores the role of histamine as a central neurotransmitter in regulating appetite and metabolism. Histamine exerts anorexigenic effects primarily through H₁ receptor stimulation, mediating leptin’s inhibitory impact on appetite and potentially delaying leptin resistance in high-fat diet-induced obesity. Additionally, histamine may enhance lipolysis, contributing to weight regulation.
This 2018 preclinical study investigated the effects of Metabolaid®, a combination of lemon verbena and hibiscus flower extracts, on obesity and metabolic parameters in high-fat diet-induced obese mice. The treatment led to significant reductions in body weight, white adipose tissue, and liver weight. Improvements were observed in serum and hepatic
This review article examines the role of the histaminergic system in regulating feeding behavior and taste perception. Histamine acts as an anorectic neurotransmitter via H₁ receptor stimulation and is positioned downstream of leptin signaling. The study highlights that histaminergic activity increases during feeding and is influenced by oral somatic sensations
This 2012 cross-sectional study evaluated 1,393 adults (63% female, mean age 51.4 years) to compare BMI, percent body fat (via DXA), and leptin levels in assessing obesity. While BMI identified 26% as obese, DXA revealed 64% were obese, indicating BMI underestimated obesity prevalence. Notably, 39% were misclassified as non-obese by
This 2022 review in Nature Reviews Endocrinology examines how insufficient sleep and circadian misalignment contribute to obesity and metabolic disorders. It highlights that insufficient sleep and circadian misalignment predispose individuals to poor metabolic health and promote weight gain. The review discusses the impact of insufficient sleep and circadian misalignment in
This 2014 review examines two decades of research on leptin, an adipocyte-derived hormone pivotal in regulating energy balance and metabolism. While leptin therapy has shown remarkable efficacy in rare conditions like congenital leptin deficiency and lipodystrophy, its effectiveness in common obesity and type 2 diabetes (T2D) has been limited due
This 2006 review article explores the central nervous system (CNS) mechanisms regulating food intake and body weight. It highlights the hypothalamus, particularly the arcuate nucleus, as a critical center integrating hormonal signals like leptin and insulin with neural inputs to maintain energy homeostasis. The review discusses how disruptions in these
This 2014 randomized, crossover study evaluated the effects of medium-chain triglycerides (MCTs) versus long-chain triglycerides (LCTs) on appetite and subsequent food intake in overweight men. Participants consumed 20 g of MCT or corn oil (LCT) at breakfast, followed by blood sampling over 3 hours. In one arm, an ad libitum
A 12-week double-blind, randomized, placebo-controlled trial evaluated the impact of black soy peptide (BSP) supplementation on body composition in overweight and obese adults (n=80). Participants received either BSP (4.5 g/day) or placebo. The BSP group showed significant reductions in body weight, BMI, body fat mass, and body fat percentage compared
This 2013 study investigated the effects of Lactobacillus gasseri BNR17, a probiotic strain isolated from human breast milk, on obesity in C57BL/6J mice fed a high-sucrose diet. Over 10 weeks, mice receiving BNR17 (10⁹ or 10¹⁰ CFU/day) exhibited significant reductions in body weight gain and white adipose tissue mass compared
