This cross-sectional study assessed the link between long-term lead exposure and severity of intracranial carotid atherosclerosis in 213 patients undergoing digital subtraction angiography. Body lead stores, estimated via bone lead levels, were significantly higher in individuals with ≥50% intracranial carotid stenosis compared to those with
This cross-sectional study assessed the association between cumulative and current lead exposure and cognitive function in 141 middle-aged and elderly men enrolled in the VA Normative Aging Study. Researchers measured blood lead levels and bone lead concentrations (in tibia and patella) using K-X-ray fluorescence. Results showed that higher blood lead
This 2015 pilot study investigated the effects of CaNa₂EDTA chelation therapy on oxidative and genotoxic damage in smelting factory workers with chronic lead exposure averaging 5.8 ± 1.2 years. Following a five-day CaNa₂EDTA regimen, significant reductions were observed in oxidative stress biomarkers, including normalized activities of antioxidant enzymes (Cu,Zn-SOD and
This review explores the potential link between environmental lead (Pb) exposure and late-onset Alzheimer’s disease (LOAD), emphasizing the role of epigenetic mechanisms. Epidemiological studies indicate that cumulative lifetime Pb exposure is associated with accelerated cognitive decline in adults. Animal models suggest that early-life Pb exposure may lead to epigenetic modifications,
This longitudinal study assessed the impact of cumulative lead exposure on cognitive function over 22 years in an occupational cohort. Researchers measured both blood lead and tibia bone lead levels and administered the Pittsburgh Occupational Exposures Test battery. Findings revealed that higher bone lead levels were associated with lower current
This review explores the potential link between lead (Pb) exposure and angiogenesis, the process of new blood vessel formation. Epidemiological and experimental studies suggest that Pb exposure may disrupt the regulation of angiogenic factors, particularly vascular endothelial growth factor (VEGF), leading to either excessive or insufficient angiogenesis. Such dysregulation is
This study investigates the association between chronic lead (Pb) exposure and fatty liver disease, focusing on the role of gut microbiota variations. A cross-sectional study involving 3,066 rural participants in East China measured blood lead levels (BLL) and diagnosed hepatic steatosis using abdominal ultrasonography. The study found that participants in
This archaeological toxicology study analyzed lead content in ancient human bones to assess historical exposure levels and social implications. Results showed that Roman-era skeletons exhibited bone lead levels approximately 1000 times higher than those from pre-industrial populations, such as in ancient Peru. The use of barium-to-lead ratios in bone apatite
This study examined factors influencing cumulative lead burden in male veterans, utilizing bone lead measurements via K-shell X-ray fluorescence. Findings indicated that age, occupational exposure, and lifestyle factors such as smoking were significant predictors of elevated bone lead levels. The research underscores the importance of considering these variables when assessing
This guideline outlines evidence-based recommendations for managing adult lead exposure, emphasizing that adverse health effects can occur at blood lead levels (BLLs) below 40 μg/dL. Key recommendations include: removing individuals from occupational lead exposure if a single BLL exceeds 30 μg/dL or if two consecutive BLLs measured over a 4-week
