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Targeting Zonulin and Intestinal Epithelial Barrier Function to Prevent Onset of Arthritis

This 2020 study elucidates the role of zonulin, a modulator of intestinal tight junctions, in the progression from autoimmunity to inflammatory arthritis. Elevated serum zonulin levels were observed in both rheumatoid arthritis (RA) patients and individuals at risk, correlating with increased intestinal permeability and decreased expression of tight junction proteins

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June 26, 2025 No Comments

Zonulin as a Potential Therapeutic Target in Microbiota-Gut-Brain Axis Disorders: Encouraging Results and Emerging Questions

This review discusses zonulin, a protein that regulates tight junctions and modulates the permeability of both the intestinal and blood-brain barriers. It highlights how dysregulation of zonulin, triggered by microbial components, may contribute to neurological and gastrointestinal disorders. The review also explores potential therapeutic interventions targeting the zonulin pathway, particularly

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June 26, 2025 No Comments