This 2017 randomized, double-blind, placebo-controlled crossover study investigated the effects of L-citrulline supplementation on exercise-induced blood flow in older adults. Twenty-five participants (13 women and 12 men) received 6 grams per day of L-citrulline or a placebo for 14 days. Femoral artery blood flow and vascular conductance were measured during
This single-blind study evaluated the efficacy of oral L-citrulline supplementation in 24 men with mild erectile dysfunction (ED), characterized by an erection hardness score (EHS) of 3. Participants received a placebo for one month, followed by 1.5 g/day of L-citrulline for another month. Results showed that 50% of the men
This randomized controlled trial investigated the effects of L-citrulline and L-arginine supplementation on high-intensity cycling performance in 24 male collegiate soccer players. Participants received either a daily dose of 1.2 g of L-citrulline and 1.2 g of L-arginine or a placebo for seven days, with the final dose taken one
This in vitro study examined the effects of L-arginine and L-citrulline supplementation on endothelial cell aging, finding that these amino acids successfully delayed endothelial senescence by enhancing nitric oxide production, which plays a crucial role in vascular function. The results suggest potential therapeutic benefits for cardiovascular health and the prevention
The study titled “L-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans” (Journal of Applied Physiology, 2015, PMID: 26023227) examined the effects of short-term L-citrulline (Cit) supplementation on blood pressure, oxygen uptake (V̇O2) kinetics, and exercise performance in healthy adults. This randomized controlled trial found that Cit
This randomized controlled trial, published in the Journal of the International Society of Sports Nutrition (2016, PMID: 26900386), investigated the effects of L-citrulline supplementation on cycling performance in healthy trained male cyclists. The study used a double-blind, placebo-controlled, two-way crossover design, where participants received either L-citrulline or a placebo. Results
