Tag: Klotho

Klotho, Aging, and the Failing Kidney

This 2020 review discusses the role of the Klotho protein in aging and kidney function. Klotho, primarily expressed in the kidneys, regulates phosphate homeostasis and vitamin D metabolism through its interaction with fibroblast growth factor-23 (FGF23). With aging, Klotho levels decline, leading to phosphate toxicity and contributing to chronic kidney

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