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Tag: isotretinoin

Use of Oral Supplements and Topical Adjuvants for Isotretinoin-Associated Side Effects: A Narrative Review

This 2024 narrative review evaluates the efficacy and safety of various oral supplements and topical adjuvants in mitigating mucocutaneous and musculoskeletal side effects associated with isotretinoin therapy. Oral supplements such as omega-3 fatty acids, vitamin E, folic acid with vitamin B12, antihistamines, L-carnitine, biotin, and combination supplements were found to

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June 26, 2025 No Comments

Efficacy and Safety of Silymarin-Containing Antioxidant Serum as an Adjuvant Treatment of Mild-to-Moderate Acne Vulgaris: A Prospective, Open-Label Pilot Study

This 2023 prospective, open-label pilot study assessed the efficacy and safety of a 0.5% silymarin-loaded antioxidant serum (SAS) as an adjunct treatment in 22 Korean patients with mild-to-moderate acne vulgaris. Over four weeks, patients applied the serum twice daily in addition to their regular acne treatments. The study reported reductions

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June 26, 2025 No Comments

Evaluation of biophysical skin parameters and hair changes in patients with acne vulgaris treated with isotretinoin, and the effect of biotin use on these parameters

This cohort study evaluated the effects of isotretinoin on skin and hair health, highlighting that biotin supplementation improved hair growth, increasing anagen hair and decreasing telogen hair (P=0.034, P=0.003). While isotretinoin reduced skin hydration, both groups saw decreased skin sebum. This suggests biotin could help mitigate isotretinoin’s adverse effects on

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June 26, 2025 No Comments