Well Referenced

Tag: ischemic stroke

Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: systematic review and dose-response meta-analysis for the Global Burden of Disease Study 2013

This 2016 systematic review and dose-response meta-analysis incorporated data from 174 prospective cohort studies to evaluate the relationship between physical activity and the incidence of breast cancer, colon cancer, type 2 diabetes, ischemic heart disease, and ischemic stroke. It demonstrated an inverse, non-linear relationship between total physical activity (measured in

Read More »
June 26, 2025 No Comments

The effects of magnesium prophylaxis in migraine without aura

This 2008 prospective cohort study published in the American Journal of Epidemiology analyzed data from 58,615 Japanese adults in the Japan Public Health Center-based Study Cohort I to evaluate the association between dietary magnesium intake and stroke risk over an average follow-up of 10.7 years. Among men, higher magnesium intake

Read More »
June 26, 2025 No Comments

α-Lipoic Acid Promotes Neurological Recovery After Ischemic Stroke by Activating the Nrf2/HO-1 Pathway to Attenuate Oxidative Damage

This 2017 in vivo and in vitro study published in Cell Physiology and Biochemistry (DOI: 10.1159/000481840, PMID: 28992629) investigated the neuroprotective effects of alpha-lipoic acid (ALA) in models of ischemic stroke. Administered after middle cerebral artery occlusion in rats, ALA significantly reduced infarct volume, brain edema, and oxidative stress while

Read More »
June 26, 2025 No Comments

Curcumin-Loaded Gelatin Nanoparticles Cross the Blood-Brain Barrier to Treat Ischemic Stroke by Attenuating Oxidative Stress and Neuroinflammation

This study investigated the use of curcumin-loaded gelatin nanoparticles (Cur@GAR NPs) functionalized with rabies virus glycoprotein (RVG29) to enhance brain-targeted therapy for ischemic stroke. In vitro, these nanoparticles demonstrated improved solubility, stability, antioxidant, and antimicrobial properties, while in vivo experiments using a rat model of middle cerebral artery occlusion (MCAO)

Read More »
June 26, 2025 No Comments

Discovery that a melanocortin regulates sexual functions in male and female humans

This study investigated the use of curcumin-loaded gelatin nanoparticles (Cur@GAR NPs) functionalized with rabies virus glycoprotein (RVG29) to enhance brain-targeted therapy for ischemic stroke. In vitro, these nanoparticles improved curcumin’s solubility, stability, antioxidant, and antimicrobial properties. In vivo studies using a middle cerebral artery occlusion (MCAO) rat model demonstrated that

Read More »
June 26, 2025 No Comments

Menopause and stroke and the effects of hormonal therapy

This review discusses the impact of menopausal hormone therapy (HT) on stroke risk, particularly in postmenopausal women. It highlights that HT, especially with conjugated equine estrogen/medroxyprogesterone acetate (CEE/MPA) or CEE alone, increases the risk of ischemic stroke, particularly in women over 60. However, recent studies suggest that lower doses of

Read More »
June 26, 2025 No Comments

Prostate cancer in men using testosterone supplementation

This study investigates the neuroprotective effects of progesterone (P4) in a rat model of ischemic stroke induced by transient middle cerebral artery occlusion (tMCAO). The results demonstrate that P4 significantly reduces infarct volume, preserves mitochondrial function, and decreases oxidative stress by inhibiting the mitochondrial permeability transition pore (mPTP). P4 also

Read More »
June 26, 2025 No Comments

Custom-compounded bioidentical hormone therapy: why so popular despite potential harm? The case against routine use

This review critically examines the growing popularity of custom-compounded bioidentical hormone therapy (CBHT) and highlights significant safety concerns, including severe adverse events from compounding errors, such as deaths from contaminated products and cases of end-stage renal failure. Oral estrogens, particularly in excessive doses, are linked to an increased risk of

Read More »
June 26, 2025 No Comments