Well Referenced

Tag: iron chelation

Novel chelators based on adamantane-derived semicarbazones and hydrazones that target multiple hallmarks of Alzheimer’s disease

This study introduces a series of adamantane-derived semicarbazones and hydrazones designed to address multiple pathological features of Alzheimer’s disease (AD). Among the synthesized compounds, 2-pyridinecarboxaldehyde (N-adamantan-1-yl)benzoyl-4-amidohydrazone (compound 10) emerged as a lead candidate, demonstrating potent iron-chelating properties, inhibition of copper(II)-induced β-amyloid aggregation, low cytotoxicity, and antioxidant activity. Additionally, compound 10

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June 26, 2025 No Comments

Iron Overload and Breast Cancer: Iron Chelation as a Potential Therapeutic Approach

This 2022 review explores the role of iron overload in breast cancer development and progression. Excess iron, particularly non-transferrin-bound iron (NTBI), can catalyze free radical reactions, leading to oxidative stress and DNA damage. Estrogen can exacerbate this by disrupting iron metabolism, further increasing reactive oxygen species (ROS) production. The study

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June 26, 2025 No Comments

Iron: The Cancer Connection

This 2020 review article explores the multifaceted role of iron in cancer biology. It discusses how dysregulated iron metabolism contributes to tumor initiation, growth, and metastasis. Excess iron can promote oxidative DNA damage and genomic instability, facilitating oncogenesis. The article also examines therapeutic strategies targeting iron metabolism, such as iron

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June 26, 2025 No Comments

Chelation in metal intoxication–Principles and paradigms

This review article discusses the role of chelation therapy in treating metal intoxication, focusing on the advancements and use of newer, less toxic chelating agents like DMSA and DMPS, which are effective for treating heavy metal poisoning and available in oral form. It highlights DMSA’s potency in treating copper overload

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June 26, 2025 No Comments