This 2008 study investigated the interactions between vitamin C (ascorbic acid) and intravenous (IV) iron formulations, specifically iron sucrose (FeSuc) and ferric gluconate (FeGlu). The researchers found that both FeSuc and FeGlu accelerated the oxidation of vitamin C in human plasma and whole blood, with FeSuc exhibiting a higher oxidative
This review examines the evolution of intravenous (IV) iron therapies, focusing on newer formulations such as ferumoxytol, ferric carboxymaltose, and iron isomaltoside. These agents possess more stable iron-carbohydrate complexes, allowing for higher single-dose administrations with reduced labile iron release, thereby minimizing infusion-related adverse events. Their enhanced safety profiles and dosing
This review discusses the clinical experience with intravenous ferric carboxymaltose (FCM) for treating iron deficiency anemia (IDA) in adults intolerant to or unresponsive to oral iron, or with nondialysis-dependent chronic kidney disease. FCM allows administration of up to 750 mg per dose (totaling 1500 mg over two doses), delivered over
This FDA-conducted study assessed the in vitro cellular iron uptake of brand (Ferrlecit®) and generic sodium ferric gluconate (SFG) formulations using three human macrophage cell lines (THP-1, HL-60, U937). Utilizing a colorimetric assay, the researchers found no significant differences in iron uptake across all cell lines, concentrations (10, 20, 40
This randomized, multicenter, double-blind clinical trial assessed the safety and efficacy of intravenous ferumoxytol compared to ferric carboxymaltose (FCM) in patients with iron deficiency anemia (IDA) unresponsive or intolerant to oral iron. A total of 1,997 patients received either ferumoxytol (n=997) or FCM (n=1000) over ≥15 minutes on days 1
These guidelines, developed by the British Society of Gastroenterology, provide comprehensive recommendations for the diagnosis and management of iron deficiency anemia (IDA) in adults. Key points include the importance of confirming IDA with appropriate laboratory tests (e.g., serum ferritin), investigating underlying causes such as gastrointestinal bleeding, and initiating treatment with
This review article discusses the evaluation and management of anemia in older adults, a condition associated with increased morbidity and mortality. It highlights that anemia is frequently asymptomatic but can present with fatigue, weakness, or shortness of breath. Common causes include iron deficiency, chronic kidney disease, inflammation, and gastrointestinal blood
