This 1976 study by Cameron and Pauling evaluated the effect of high-dose vitamin C (10 g/day, initially IV then oral) on survival in 100 terminal cancer patients compared to 1,000 matched controls. Results showed significantly prolonged survival in the ascorbate group, with a mean survival extension of around 300 days
This 2021 narrative review examines the use of high-dose intravenous vitamin C (IVC) in advanced-stage cancer patients. While preclinical studies demonstrate that pharmacologic concentrations of ascorbate can exert cytotoxic effects on malignant cells and enhance the efficacy of chemotherapy, clinical evidence in humans remains limited. Some studies suggest that IVC
This study presents a convenient method for measuring blood ascorbate (vitamin C) concentrations in patients receiving high-dose intravenous ascorbate. The method offers a more efficient and accurate way to monitor vitamin C levels during treatment, aiding in the optimization of therapy. The study highlights the importance of monitoring ascorbate levels
