Well Referenced

Tag: intestinal barrier dysfunction

Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality

This 2015 observational study published in Cell Reports (PMID: 26321641) examined how aging in Drosophila melanogaster (fruit flies) affects gut microbiota and intestinal barrier function. Researchers found that aging flies experienced a notable shift in gut microbiota composition, particularly an expansion of Gammaproteobacteria, which preceded and predicted intestinal barrier dysfunction.

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June 26, 2025 No Comments

Relevance of biomarkers indicating gut damage and microbial translocation in people living with HIV

This 2023 review published in Frontiers in Immunology (PMID: 37153621) investigates how gut permeability and microbial translocation contribute to systemic immune activation in people living with HIV (PLWH). It highlights key biomarkers—such as intestinal fatty acid-binding protein (I-FABP), zonulin, REG3α, lipopolysaccharide (LPS), and (1,3)-β-D-Glucan (BDG)—as tools to assess gut barrier

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June 26, 2025 No Comments