Well Referenced

Tag: Internal Medicine

Determination and Interpretation of MTHFR Gene Mutations in Gynecology and Internal Medicine

This expert consensus article by the Hemostasis Group of the Polish Society of Hematologists and Transfusiologists addresses the clinical significance of two common MTHFR gene polymorphisms—c.665C>T (formerly 677C>T) and c.1286A>C (formerly 1298A>C). These polymorphisms can reduce MTHFR enzyme activity, leading to elevated homocysteine levels, particularly in individuals with folate deficiency.

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June 26, 2025 No Comments

Selenium and Human Health

In this 2012 review published in The Lancet, Margaret P. Rayman explores selenium’s multifaceted role in human health, emphasizing its incorporation into selenoproteins that are vital for antioxidant defense, immune function, and thyroid hormone metabolism. The article highlights that low selenium status is associated with increased risks of mortality, impaired

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June 26, 2025 No Comments

Selenium and Selenoproteins in Health

This 2023 review article in Biomolecules by Zhang, Li, and Wei provides a comprehensive overview of selenium’s role in human health, emphasizing its incorporation into selenoproteins that are pivotal for various physiological processes. Selenium, an essential trace element, is integral to the function of at least 25 known human selenoproteins,

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June 26, 2025 No Comments

The Importance of Selenium to Human Health

This 2000 review by M.P. Rayman, published in The Lancet, provides a comprehensive overview of selenium’s critical role in human health. Selenium, an essential trace mineral, is integral to the function of selenoproteins, which have structural and enzymatic roles, notably as antioxidants and in the activation of thyroid hormones. The

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June 26, 2025 No Comments

The Role of Selenium in Pathologies: An Updated Review

This comprehensive 2022 review in Antioxidants explores selenium’s multifaceted role in human health, emphasizing its incorporation into at least 25 selenoproteins that regulate oxidative stress, hormone synthesis, and immune function. The authors detail selenium’s involvement in various pathologies, including cancer, diabetes, cardiovascular diseases, neurodegenerative disorders, fertility issues, and infections like

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June 26, 2025 No Comments

N-Acetylcysteine (NAC): Impacts on Human Health

In this 2021 review, Tenório et al. examine the multifaceted roles of N-acetylcysteine (NAC) in human health. NAC, recognized by the FDA and WHO, is primarily used to treat acetaminophen overdose and as a mucolytic agent in respiratory diseases. Its therapeutic potential extends to conditions characterized by oxidative stress and

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June 26, 2025 No Comments

Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits

In this 2014 review published in Pharmacology & Therapeutics, Rushworth and Megson critically assess the therapeutic applications of N-acetylcysteine (NAC), emphasizing its role as a precursor to intracellular glutathione (GSH) rather than as a direct antioxidant. The authors highlight that NAC’s efficacy in conditions such as acetaminophen overdose is well-established

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June 26, 2025 No Comments

Assessment of insulin resistance using surrogate markers in patients of metabolic syndrome

This study evaluated the efficacy of two surrogate markers—Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and Insulin Sensitivity Index (ISI₀,₁₂₀)—in assessing insulin resistance among patients with metabolic syndrome (MetS). Conducted at Lady Hardinge Medical College, New Delhi, the research involved 50 MetS patients and 50 age- and sex-matched healthy controls.

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June 26, 2025 No Comments

BPC 157 therapy to detriment sphincters failure-esophagitis-pancreatitis in rat and acute pancreatitis patients low sphincters pressure

This study investigates the therapeutic effects of the stable gastric pentadecapeptide BPC 157 on esophagitis, sphincter failure, and acute pancreatitis in both rat models and human patients. In rats, esophagitis and sphincter failure were induced by inserting tubes into the lower esophageal and pyloric sphincters, while acute pancreatitis was triggered

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June 26, 2025 No Comments

Alteration of the intestinal microbiota as a cause of and a potential therapeutic option in irritable bowel syndrome

This 2014 review by König and Brummer explores the role of intestinal microbiota alterations in the pathogenesis of irritable bowel syndrome (IBS) and evaluates microbiota-targeted therapies. The authors highlight that IBS patients often exhibit dysbiosis, characterized by reduced microbial diversity and imbalances in beneficial and harmful bacterial populations. Such alterations

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June 26, 2025 No Comments