Well Referenced

Tag: Intermittent Dosing

Comparison of Continuous and Intermittent Anorectic Therapy in Obesity

This 1968 randomized controlled trial assessed the efficacy of continuous versus intermittent anorectic therapy in 108 obese patients over 28 weeks. Participants were divided into three groups: continuous phentermine, intermittent phentermine (alternating with placebo), and continuous placebo. Both phentermine groups achieved significantly greater weight loss compared to placebo. Notably, the

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June 26, 2025 No Comments

Rapamycin and Ageing: When, for How Long, and How Much?

This 2014 review by Matt Kaeberlein evaluates critical variables in rapamycin use for aging interventions, including optimal dosing, treatment duration, and initiation timing. While rapamycin consistently extends lifespan in animal models, most studies employ a standard dose and continuous administration, potentially missing more effective strategies. Emerging evidence suggests intermittent or

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June 26, 2025 No Comments