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Tag: interleukin-2

Role of Melatonin in Cancer Treatment

This 2012 review explores melatonin’s multifaceted role in cancer therapy, highlighting its anti-proliferative, antioxidant, and immunomodulatory properties. Preclinical studies demonstrate melatonin’s ability to inhibit cancer cell proliferation, modulate estrogen receptor expression, and suppress tumor growth via antioxidant pathways. It also influences the expression of enzymes like aromatase, impacting estrogen biosynthesis.

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June 26, 2025 No Comments

Intravenous Ascorbic Acid as an Adjuvant to Interleukin-2 Immunotherapy

This 2014 study investigates the potential synergistic effects of combining high-dose intravenous ascorbic acid (vitamin C) with interleukin-2 (IL-2) immunotherapy in cancer treatment. The authors discuss how ascorbic acid may enhance the efficacy of IL-2 by modulating immune responses, reducing oxidative stress, and improving patient tolerance to therapy. Preliminary findings

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June 26, 2025 No Comments

Immunotherapy with Subcutaneous Low-Dose Interleukin-2 and the Pineal Indole Melatonin as a New Effective Therapy in Advanced Cancers of the Digestive Tract

This 1993 clinical trial evaluated the efficacy and tolerability of combining low-dose interleukin-2 (IL-2) with melatonin (MLT) in 35 patients with advanced digestive tract cancers, including colorectal, gastric, hepatocellular, and pancreatic adenocarcinomas. MLT was administered orally at 50 mg daily, starting seven days before IL-2, which was given subcutaneously at

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June 26, 2025 No Comments