Well Referenced

Tag: Insulin-Like Growth Factor I

Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial

This randomized, double-blind, placebo-controlled trial assessed the effects of the oral ghrelin mimetic MK-677 (25 mg daily) on growth hormone (GH) secretion, body composition, and clinical outcomes in 65 healthy adults aged 60–81 over 12 months. MK-677 significantly increased 24-hour mean GH and insulin-like growth factor I (IGF-I) levels to

Read More »
June 26, 2025 No Comments

Serum Insulin-Like Growth Factor-I Levels Are Associated with Improved White Matter Recovery After Traumatic Brain Injury

This 2017 longitudinal cohort study by Feeney et al. examined whether serum insulin-like growth factor-I (IGF-I) levels influence white matter (WM) recovery and cognitive outcomes in adults with moderate to severe traumatic brain injury (TBI). Using diffusion tensor imaging (DTI) and neuropsychological assessments over a 13-month period, the study found

Read More »
June 26, 2025 No Comments

Once daily subcutaneous growth hormone-releasing hormone therapy accelerates growth in growth hormone-deficient children during the first year of therapy. Geref International Study Group

This randomized controlled trial evaluated the effectiveness of daily subcutaneous administration of growth hormone-releasing hormone (GHRH(1-29)) in 110 children with growth hormone deficiency. Over a 12-month period, the treatment significantly increased height velocity, with an average increase to 8.0 cm/year at 6 months and 7.2 cm/year at 12 months. At

Read More »
June 26, 2025 No Comments