Well Referenced

Tag: inflammation

Gut Microbiota and Obesity: A Role for Probiotics

This 2019 review explores the interplay between gut microbiota and obesity, highlighting how dysbiosis—characterized by reduced microbial diversity and an increased Firmicutes-to-Bacteroidetes ratio—contributes to obesity development. The authors discuss the potential of probiotics to modulate gut microbiota composition, thereby influencing host metabolism, energy balance, and inflammatory responses. Evidence from animal

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June 26, 2025 No Comments

Targeting Zonulin and Intestinal Epithelial Barrier Function to Prevent Onset of Arthritis

This 2020 study elucidates the role of zonulin, a modulator of intestinal tight junctions, in the progression from autoimmunity to inflammatory arthritis. Elevated serum zonulin levels were observed in both rheumatoid arthritis (RA) patients and individuals at risk, correlating with increased intestinal permeability and decreased expression of tight junction proteins

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June 26, 2025 No Comments

Effect of Butyrate Enemas on the Colonic Mucosa in Distal Ulcerative Colitis

This 1992 single-blind, placebo-controlled crossover trial evaluated the therapeutic impact of sodium butyrate enemas (100 mmol/L) in 10 patients with distal ulcerative colitis unresponsive to standard treatments. Following two weeks of butyrate administration, patients experienced significant clinical improvements: stool frequency decreased from 4.7 ± 0.5 to 2.1 ± 0.4 per

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June 26, 2025 No Comments

Vitamin D and Marine Omega-3 Fatty Acid Supplementation and Incident Autoimmune Disease: VITAL Randomized Controlled Trial

This large-scale, randomized, double-blind, placebo-controlled trial investigated whether daily supplementation with vitamin D₃ (2000 IU) and/or marine omega-3 fatty acids (1000 mg) reduces the incidence of autoimmune diseases. Over a median follow-up of 5.3 years among 25,871 U.S. adults aged ≥50 (men) and ≥55 (women), vitamin D supplementation led to

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June 26, 2025 No Comments

Innate Inflammation Induced by the 8-Oxoguanine DNA Glycosylase-1–KRAS–NF-κB Pathway

This study elucidates a novel mechanism by which the DNA repair enzyme 8-oxoguanine DNA glycosylase-1 (OGG1) contributes to innate inflammation. Upon repairing oxidatively damaged DNA (specifically 8-oxoG lesions), OGG1 forms a complex with the excised base, acquiring guanine nucleotide exchange factor activity that activates KRAS. Activated KRAS then triggers downstream

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June 26, 2025 No Comments

The Benefits of Marine Omega-3s for the Prevention and Treatment of Cardiovascular Disease

This narrative review explores the cardiovascular effects of marine omega-3 fatty acids, focusing on eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Clinical evidence, particularly from the REDUCE-IT trial, demonstrates that high-dose EPA (4 g/day of icosapent ethyl) can significantly reduce major adverse cardiovascular events (MACE) by 25% in high-risk individuals.

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June 26, 2025 No Comments

The Role of Nutraceutical Supplements in the Treatment of Dyslipidemia

This 2012 review by Dr. Mark Houston explores the clinical utility of nutraceutical supplements in the management of dyslipidemia. The paper emphasizes a functional medicine approach combining diet with evidence-based nutraceuticals to reduce LDL cholesterol, LDL particle number, VLDL, and triglycerides, while increasing HDL (especially HDL2b) and LDL particle size.

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June 26, 2025 No Comments

EDTA Chelation Therapy for the Treatment of Neurotoxicity

This 2019 review examines the therapeutic potential of calcium disodium ethylenediaminetetraacetic acid (EDTA) chelation therapy in mitigating neurotoxicity caused by toxic metals, pesticides, air pollution, radiation, and certain drugs. EDTA chelation therapy may exert neuroprotective effects by removing toxic metals, reducing oxidative stress, and modulating inflammatory responses. The authors present

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June 26, 2025 No Comments

Personalization of multiple sclerosis treatments: using the chelation therapy approach

This 2023 study by Vezzoli et al. investigates the efficacy of combining calcium disodium EDTA (CaNa₂EDTA) chelation therapy with antioxidant micronutrient supplementation in patients with multiple sclerosis (MS). The research involved 20 MS patients and 20 healthy controls, assessing oxidative stress markers, inflammatory cytokines, and nitric oxide metabolites. Post-treatment results

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June 26, 2025 No Comments