Proinflammatory cytokines, aging, and age-related diseases
This 2013 review article published in the Journal of the American Medical Directors Association (PMID: 23792036) explores the role of proinflammatory cytokines—such as IL-6, IL-1, TNF-α, and CRP—in aging and their link to age-related diseases. Chronic low-grade inflammation, termed “inflamm-aging,” is associated with increased frailty, sarcopenia, cardiovascular conditions, and neurodegenerative