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Tag: in vivo study

Metformin enhances tamoxifen-mediated tumor growth inhibition in ER-positive breast carcinoma

This 2014 preclinical study investigates the combined effects of metformin and tamoxifen on estrogen receptor-positive (ER+) breast cancer cells. The combination therapy significantly inhibited cell proliferation, DNA replication, colony formation, and induced apoptosis more effectively than either agent alone. Mechanistically, the enhanced effects are associated with activation of the AMPK

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June 26, 2025 No Comments

Cytotoxic Effects of the Viscum Album L. Extract on Ehrlich Tumour Cells in Vivo

This in vivo animal study investigated the cytotoxic effects of non-polar constituents from Viscum album L. (European mistletoe) on Ehrlich ascites carcinoma (EAC) cells in mice. Extracted using supercritical CO₂ and analyzed by GC/MS, the mistletoe contained novel terpenes that, when administered before and after tumor cell inoculation, significantly reduced

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June 26, 2025 No Comments

Evaluation of Chlorella as a Decorporation Agent to Enhance the Elimination of Radioactive Strontium from Body

This study explored the potential of Chlorella, a green microalga, as a decorporation agent for radioactive strontium (^90Sr). In vitro experiments showed that Chlorella effectively adsorbed ^85Sr, and in vivo studies in mice demonstrated that Chlorella significantly reduced bone accumulation of ^85Sr, promoting its excretion. These results suggest that Chlorella

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June 26, 2025 No Comments

Ocimum tenuiflorum extract (HOLIXERTM): Possible effects on hypothalamic-pituitary-adrenal (HPA) axis in modulating stress

This study evaluated the anti-stress effects of Holixer™, a standardized extract of Ocimum tenuiflorum (Holy Basil), using in vivo models (swim endurance in mice and forced swim tests in rats) and in vitro HPA-axis assays. Results showed that Holixer™ significantly improved physical endurance, reduced stress-induced immobility, and normalized corticosterone levels.

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June 26, 2025 No Comments