in vitro Archives - Well Referenced

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

This 2020 study by Yao et al. evaluated the antiviral efficacy of hydroxychloroquine (HCQ) against SARS-CoV-2 in vitro and proposed optimized dosing regimens using physiologically based pharmacokinetic (PBPK) modeling. HCQ demonstrated greater potency than chloroquine, with an EC50 of 0.72 μM compared to 5.47 μM. The PBPK model suggested that

June 26, 2025 No Comments

Protoapigenone, a Novel Flavonoid, Inhibits Ovarian Cancer Cell Growth In Vitro and In Vivo

This 2008 study evaluates the anticancer potential of protoapigenone, a naturally occurring flavonoid isolated from fern species, in ovarian cancer models. In vitro, protoapigenone suppressed proliferation and colony formation of ovarian cancer cell lines (MDAH-2774 and SKOV3) by inducing apoptosis and G2/M cell cycle arrest. Mechanistically, it activated stress signaling

June 26, 2025 No Comments

No evidence of stimulation of human tumor cell proliferation by a standardized aqueous mistletoe extract in vitro

This 2003 in vitro study assessed whether a standardized aqueous extract of mistletoe (Viscum album) influences the proliferation of various human tumor cell lines. Across multiple cancer cell types, the extract did not enhance cell proliferation, and in some cases, showed neutral or slight inhibitory effects. These findings counter concerns

June 26, 2025 No Comments

Tag: in vitro

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Protoapigenone, a Novel Flavonoid, Inhibits Ovarian Cancer Cell Growth In Vitro and In Vivo

No evidence of stimulation of human tumor cell proliferation by a standardized aqueous mistletoe extract in vitro