Well Referenced

Tag: immunosuppression

Chronic stress-induced immune dysregulation in cancer: implications for initiation, progression, metastasis, and treatment

This comprehensive review explores how chronic psychological stress disrupts immune regulation, thereby influencing cancer initiation, progression, metastasis, and therapeutic resistance. Chronic stress activates the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system, leading to elevated levels of glucocorticoids and catecholamines. These hormonal changes impair immune surveillance by promoting the expansion of

Read More »
June 26, 2025 No Comments

Long-term Host Immune Response Trajectories Among Hospitalized Patients With Sepsis

This 2019 prospective cohort study published in JAMA Network Open (PMID: 31390038) analyzed long-term immune response trajectories in 483 sepsis survivors across 12 U.S. hospitals. Researchers tracked biomarkers of inflammation (hs-CRP) and immunosuppression (sPD-L1) over 12 months and identified two phenotypes: one with persistent hyperinflammation and immunosuppression, and another with

Read More »
June 26, 2025 No Comments