Well Referenced

Tag: IL-1β

Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-kappaB and p38 MAPK in HMC-1 human mast cell line

This in vitro study investigated the effects of quercetin on human mast cells (HMC-1) stimulated to produce inflammatory cytokines. The researchers found that quercetin significantly inhibited the expression and production of TNF-α, IL-1β, IL-6, and IL-8 by attenuating the activation of NF-kappaB and p38 MAPK pathways—two major regulators of inflammation.

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June 26, 2025 No Comments

NLRP3 inflammasome of microglia promotes A1 astrocyte transformation, neo-neuron decline and cognition impairment in endotoxemia

This 2022 in vivo animal study published in Biochemical and Biophysical Research Communications (DOI: 10.1016/j.bbrc.2022.02.092) examined the role of the NLRP3 inflammasome in cognitive decline during endotoxemia. Using a mouse model, researchers found that LPS-induced systemic inflammation elevated IL-1β levels in the cerebrospinal fluid, triggered microglial NLRP3 inflammasome activation, and

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June 26, 2025 No Comments

The NLRP3 Inflammasome as a Critical Actor in the Inflammaging Process

This review article discusses the role of the NLRP3 inflammasome in aging, focusing on its activation and contribution to “inflammaging” — a state of chronic low-grade inflammation associated with age-related diseases like cancer, cardiovascular disease, and neurodegenerative disorders. The NLRP3 inflammasome, activated by signals such as mitochondrial dysfunction and lysosomal

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June 26, 2025 No Comments

Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials

This systematic review and meta-analysis examined the effects of curcumin/turmeric supplementation on inflammatory and oxidative stress markers across 66 randomized controlled trials. The results showed significant reductions in C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6), along with improvements in total antioxidant capacity (TAC), superoxide dismutase (SOD) activity,

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June 26, 2025 No Comments

Drivers of age-related inflammation and strategies for healthspan extension

This review discusses the role of chronic inflammation driven by the NLRP3 inflammasome in age-related conditions such as arthritis, diabetes, cardiovascular disease, and Alzheimer’s disease. It highlights how the accumulation of damage-associated molecular patterns (DAMPs) with age activates NLRP3, increasing IL-1β and IL-18 production and contributing to systemic inflammation. The

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June 26, 2025 No Comments

Effects of Dietary Patterns on Biomarkers of Inflammation and Immune Responses: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

This meta-analysis of 22 randomized controlled trials assessed the impact of dietary patterns on inflammatory biomarkers. The Mediterranean diet showed significant reductions in IL-6, IL-1β, and CRP levels, suggesting its potential to reduce systemic inflammation and lower the risk of chronic diseases associated with elevated inflammatory markers. No substantial effects

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June 26, 2025 No Comments