IGF-I Archives - Well Referenced

Serum Insulin-Like Growth Factor-I Levels Are Associated with Improved White Matter Recovery After Traumatic Brain Injury

This 2017 longitudinal cohort study by Feeney et al. examined whether serum insulin-like growth factor-I (IGF-I) levels influence white matter (WM) recovery and cognitive outcomes in adults with moderate to severe traumatic brain injury (TBI). Using diffusion tensor imaging (DTI) and neuropsychological assessments over a 13-month period, the study found

June 26, 2025 No Comments

Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog

This study investigated the effects of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, on growth hormone (GH) secretion in healthy men. Participants were given a single subcutaneous injection of CJC-1295 at doses of 60 or 90 µg/kg. GH secretion was measured over 12 hours before and one week after

June 26, 2025 No Comments

Body composition and quality of life in adults with growth hormone deficiency; effects of low-dose growth hormone replacement

This prospective, open-label study evaluated the early effects of low-dose growth hormone replacement (GHR) on body composition and quality of life (QoL) in adults with growth hormone deficiency (AGHD). Patients received daily GH doses of 0.4–0.5 IU, titrated to maintain IGF-I levels between the median and upper end of the

June 26, 2025 No Comments

Quantitative growth hormone secretion and final adult height

This study examined the relationship between quantitative growth hormone (GH) secretion and final adult height in 40 healthy postpubertal men, aged 18-27 years. The study found no significant differences in GH responses or secretion patterns between individuals with tall and short stature, suggesting that GH secretion levels do not play

June 26, 2025 No Comments

Effects of [norleucine27]growth hormone-releasing hormone (GHRH)(1-29)-NH2 administration on the immune system of aging men and women

This study investigates the effects of [norleucine27]growth hormone-releasing hormone (GHRH) (1-29)-NH2 on immune function in elderly adults. Conducted as a single-blind, randomized, placebo-controlled trial, it involved 19 healthy elderly participants (10 women, 9 men) receiving nightly subcutaneous injections of either placebo or GHRH analog for 16 weeks. The results demonstrated

June 26, 2025 No Comments

Hormone replacement therapy and physical function in healthy older men. Time to talk hormones?

This review discusses the potential benefits of hormone replacement therapy (HRT), particularly testosterone and growth hormone (GH), in maintaining physical function in older men, especially those suffering from age-related declines in muscle mass and strength (sarcopenia). It highlights that while exercise is important, it may not be sufficient for older

June 26, 2025 No Comments

The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women

A six-month study evaluated the effects of daily 100 mg dehydroepiandrosterone (DHEA) supplementation in elderly men and women, finding that DHEA and DHEA sulfate (DS) levels increased, accompanied by a higher DS/cortisol ratio. In women, the treatment led to increased levels of potent androgens comparable to those of younger individuals,

June 26, 2025 No Comments

The IGF-I response to very low rhGH doses is preserved in human ageing

This study explored the response to very low doses of recombinant human growth hormone (rhGH) in aging individuals. It found that despite the natural decline in Insulin-Like Growth Factor I (IGF-I) levels associated with aging, the peripheral sensitivity to rhGH remained intact. The study demonstrated that even at low doses,

June 26, 2025 No Comments

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